Discovery Scientist in High Throughput Screening (Postdoc level)

Solgate GmbH

Klosterneuburg - vor 1 Monat

Solgate is a new research-driven biopharmaceutical startup that develops drugs targeting solute carrier (SLC) proteins, the largest family of membrane transporters. By modulating the function of the gates to cellular metabolism, Solgate aims to address unmet medical needs in neurological diseases, in metabolic disorders and in cancer. Solgate is located in the newly established IST Park, a space housing a growing community of technology startups and biotech companies, adjacent to IST Austria in Klosterneuburg, near Vienna.

Solgate is seeking to hire a motivated and creative Discovery Scientist in high-throughput screening (postdoc level) to join our fast-growing interdisciplinary research team. Together, we are developing novel small molecule therapeutics that modulate the functions of membrane transporters. We have a high-performance, and result-oriented culture, looking for colleagues eager to learn. The ideal candidate will bring relevant experience, creativity, entrepreneurial drive, and a passion for advancing our mission.

Role and Responsibilities

  • Employ innovative problem-solving skills utilizing cutting edge screening methodologies to identify drug targets and hit compounds
  • Develop, optimize and execute medium-high throughput screens, including phenotypic screens, biophysical screens and cell-based screens
  • Design quantitative experiments with rigorous attention to parameters to support robust scientific conclusions
  • Provide leadership in the laboratory through scientific/technical mentoring
  • Engage in multidisciplinary research projects and closely collaborate with Solgate team members to progress strategic goals
  • Implement novel methods, assays and applications to advance drug discovery efforts for membrane transporters.
  • Perform mechanism-of-action studies using cellular biology, genetic, biophysical and molecular biology approaches
  • Coordinate and implement the appropriate infrastructure to enable the screening platform, including experimental and analytical needs
  • Organize, summarize and deliver data, in written and oral presentations
  • Contribute to documentation, laboratory infrastructure management, and managerial leadership to CROs

To accomplish the responsibilities of this role, the candidate must demonstrate excellent interpersonal, organization and communication skills in addition to rigorous scientific thinking.

Qualifications

  • M.Sc./Ph.D. in Cell Biology, Biophysics, Biochemistry, or similar field with expertise in assay development and screening
  • Demonstrated relevant publication track record in leading scientific journals and excellent skills in performing and documenting experiments
  • 4+ years of academic/industry experience in more than one HTS screening methodology (such as cell-based reporters, FRET, luminescence, ELISA, SPR, ITC, MST, FP, DSF or other novel readout technologies)
  • Experience in automation & liquid handling, advanced imaging technologies (e.g. CellProfiler), data analysis (R, Python, PRISM or similar) are considered valued assets
  • Proactive, efficient team player who is able to work both independently and as part of an interdisciplinary team
  • Experience in project leadership demonstrated by creative problem solving and excellent planning and analytical skills
  • Strong background in a relevant therapeutic area and the mechanisms of disease is desirable
  • A proven track record of drug discovery success, such as having led research that delivered drug development candidates, is considered an asset
  • Fluency in English (spoken and written) is required.

At Solgate, you will have the opportunity to expand your knowledge and skills to advance your career and take part in the growth of Solgate from its early days. Solgate embraces diversity and equal opportunity and we are committed to building our team to represent a range of backgrounds, perspectives, and skills.

We can offer you market-rate gross monthly remuneration of 3638. The actual remuneration package will be guided by your professional experience and your qualifications, with readiness to pay in excess of collectively agreed amount.

To apply, please submit your letter of motivation and your curriculum vitae (including the contact details of two references) to our recruitment team using the link. For any question, just contact us (office@solgatetx.com). Please provide the documents as two PDFs, with your name. We can only consider full applications submitted through our portal. Applications are reviewed on a rolling basis until the position is filled

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